Microsoft completed a complex 2.5D design comprised of an in-house developed SoC, Third Party IP, a silicon interposer and an organic package substrate. Microsoft had previously worked with Siemens and deployed Xpedition Substrate Integrator (XSI) and Calibre 3DStack for 2.5D LVS verification. For this design Microsoft again wanted to perform 2.5D LVS and DRC verification but wanted to start doing it earlier in the design cycle as opposed to waiting for until all the pieces were complete or close to tapeout to run the 2.5D verification flow. Over the course of the project, 2.5D verification, both LVS and alignment DRC checks, were run on a regular basis to support the design teams through the design iterations and successful tapeout. Additionally, several new checks were developed specifically to identify design issues the team was concerned about. This presentation will describe how Microsoft used Siemens 3D IC verification solutions to help address design problems as well as verification of the full 2.5D system.