Transform drug development and manufacturability with integrated and AI-powered performance engineering

Pharmaceutical companies face a stark reality: only 1 in 5,000 drug candidates reaches market approval, R&D return on investment has dropped to just 1.2%, and bringing a new treatment to market costs between $2.6 and $6.7 billion. Traditional approaches to process design and technology transfer rely on extensive physical experiments, fragmented data and siloed teams, making fast and efficient scale-up nearly impossible.

Digital transformation changes that equation. A connected digital thread spanning formulation, process design and technology transfer acts as a single source of truth, breaking down silos and enabling teams to collaborate across every stage of development.

What's inside the ebook:

Siemens Simcenter offers a comprehensive, AI-powered simulation portfolio designed for the pharmaceutical industry. The ebook walks through six capability areas that help you reduce physical experimentation, accelerate scale-up and improve drug manufacturability:

• Formulations and process development - Simulate molecular interactions and predict chemical and physical properties, from formulation through production.
• Fluid dynamics, heat and mass transfer - Use Computational Fluid Dynamics (CFD) to optimize equipment performance at both lab and manufacturing scale.
• Particle flow behavior - Apply discrete element modeling (DEM) to reduce drug substance consumption and lower process development costs.
• Process simulation - Identify critical process parameters and quality attributes through in-silico testing, without committing to physical batches.
• Optimization and reduced order models - Get near-instant field predictions for any equipment configuration and boundary condition.
• Executable Digital Twin - Combine real sensor data, 3D CFD, AI and machine learning into a live virtual replica of your manufacturing process for adaptive control and operator training.

Download the ebook

This ebook covers each Siemens Simcenter capability in detail, with industry data, expert quotes from pharmaceutical practitioners and a clear picture of how simulation and Digital Twin technology fit into the pharmaceutical development lifecycle.

Download the ebook to see how Simcenter can help you accelerate drug development, reduce waste and scale up from lab to production with greater speed and confidence.