Predicting oxygen transfer from 5 L to 2000 L

Bristol Myers Squibb works with M-Star to develop and validate a mechanistic, physics-based model for predicting oxygen transfer in stirred-tank bioreactors. The model accounts for the coupled effects of bubble size, fluid properties, local energy dissipation, and dissolved oxygen concentration and was validated against experimental data across scales ranging from 5 L to 2000 L. Implemented on GPUs, the model runs at timescales practical for industrial application, demonstrating M-Star's ability to provide predictive oxygen-transfer modeling across multiple bioreactor scales.