Multi-component pharmaceutical spray drying model

In this webinar, experts discuss the development and application of a multi-component spray drying model in the gPROMS FormulatedProducts framework, which can be used to predict product properties, optimize process parameters and improve the environmental footprint of pharmaceutical spray dried amorphous dispersions throughout the development lifecycle.

<h2>Advanced Modeling of Spray Dried Amorphous Dispersions</h2>
Spray drying is commonly employed in the pharmaceutical industry to form amorphous solid dispersions (ASD) that enhance the dissolution properties of the active pharmaceutical ingredient (API) in the drug product. Effective process design is essential to ensure desired product properties such as particle size and residual solvent content, while maintaining satisfactory physical stability. By combining the use of digital tools with experimentation, the design and scale up of spray drying processes may be improved. 

<h2>This webinar covers:</h2>
- The development of a two-module spray drying model in gPROMS FormulatedProducts
- The use of radial diffusion modeling to predict shell locking and particle structure
- Predictive modeling of particle size, solvent content, and glass transition temperature
- An application of thermodynamic data (NRTL, DVS, DSC) to support model accuracy
- A case study from Eli Lilly comparing model predictions to experimental data
- How this approach supports improved product quality and reduced environmental impact