Modeling oxygen and carbon Dioxide dynamics in large-scale bioreactors

This study from Regeneron and the University of Limerick uses M-Star CFD to model CHO cell respiration in a large-scale bioreactor. The GPU-accelerated simulations closely matched experimental data, enabling exploration of how dissolved O₂ and CO₂ concentrations evolve with cell density and over time. M-Star CFD provided a powerful framework for capturing local heterogeneities and validating key process parameters, demonstrating its potential for bioprocess scale-up studies.