As traditional IC technology scaling slows, System Technology Co-Optimization (STCO) emerges as a crucial approach to extend design scaling by enabling early architectural and technology trade-offs. This process relies heavily on predictive analysis, utilizing high-level modeling to evaluate numerous chiplet-level SoC decompositions and identify the microarchitecture that best meets product requirements. STCO necessitates deep collaboration across system, RTL, package, ASIC, and test teams from the planning phase, ensuring that considerations like packaging technologies, available IP, and off-the-shelf chiplets are integrated upfront.