Accelerating mammalian cell bioprocess scale-up

This Simcenter M-Star study with Pfizer introduces a hybrid CFD model that efficiently simulates and optimizes mammalian cell bioprocesses across multiple scales. By integrating hydrodynamics, kinetics, and control systems, the model enables accurate feed control and reveals key metabolic sensitivities, notably to glutamine. Its ability to achieve scale-up predictions with significantly reduced computation time highlights its practical value for bioreactor design and optimization.